Depends what you're using. I do all of my custom stuff with House of Kolor, and for th eurethanes, it's not necessary. There is also a large difference in the plastics that bumpers and automotive mouldings are made of than sled panels. Most automotive plastics are are TPO, which is more flexible, and contains olefin, which needs other additives. Sled plastics are far more durable, (less flexible) and made of different materials, so you have to know what you're spraying on before you chose your materials.
Using a flex agent when not necessary actually makes the paint job more suseptible to damage. I do have a few other tricks that I use when doing sleds, many have been learned from trial and error on my own over the years, but I can't give away all my secrets!