Barry,
I think if all 4 carbs are T'd together with the manometer then the vacuum you are reading will be equalized, as one system. If your intent is to sync the carbs you need to measure differential between the carbs, like one manometer between 1 & 2 and another between 3 & 4 then compare to each other.
I don't think you'd have to plug the two CV slide diaphragm vent hoses as they aren't producing vacuum.